FPIES is a non-IgE-mediated gastrointestinal food hypersensitivity disorder. Food protein-activated intestinal lymphocytes elaborate inflammatory cytokines that result in increased intestinal permeability, malabsorption, dysmotility, emesis, diarrhea, pain, and failure to thrive.
In other words, FPIES is the intestinal version of anaphylactic shock. Eating food, particularly those high in protein, cause mild to severe reactions. Symptoms include some or all of these: malabsorption, colitis, shock, extreme lethargy, ulcerated colon, projectile vomiting/severe reflux, extreme diarrhea, failure to thrive, nutritional deficiencies, colic type symptoms, bloody stool, mucousy stool, rash, and stomach pains.
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